Uhn-Soo Cho
Laboratory
Uhn-Soo Cho, Ph.D.
Associate Professor
University of Michigan Medical School
Department of Biological Chemistry
Office: 4220E MSRB III
Lab: 4240 MSRB III
1150 W. Medical Center Drive
Ann Arbor, MI 48109-5606
Phone: (206) 779-3219
Email: uhnsoo@umich.edu
Research
Epigenetic regulators
Sestrin2 and GATOR
cryo-EM Grid Development
The Cho laboratory focuses on illustrating the molecular mechanisms of epigenetic regulators using structural biology as a major approach.
Using both the x-ray protein crystallography and cryogenic electron microscopy (cryo-EM) as primary tools, we aim to determine the structures of epigenetic regulators in complex with its substrate, nucleosome, at the molecular level and thereby elucidate their biochemical/physiological functions.
In addition, we are interested in elucidating the molecular mechanisms of mTORC1 regulation, particularly focusing on amino-acid dependent upstream regulators, such as Sestrins and GATOR complexes.
For the technical development, we are developing cryo-EM grids, such as graphene grids and affinity grids, to improve the sample preparation step in cryo-EM.